Preview the Week 13 matchup between the San Francisco 49ers and Cleveland Browns with predictions, odds, over/under, spread, betting lines and more.

When you looked at the 49ers’ schedule back in August, you probably circled this Week 13 trip to Cleveland as an easy road win. The Browns stink. They always stink. It’s part of the NFL’s natural order, like the sun rising or Tom Brady botching the broadcast call on a big third down.

Brock Purdy played arguably his worst game for the 49ers against the Panthers since the Christmas game against the Ravens in 2023. The 49ers should’ve steamroll

The San Francisco 49ers, led by quarterback Brock Purdy, face the Cleveland Browns, led by quarterback Shedeur Sanders, on Sunday, Nov. 30, 2025 at Huntington Bank Field in Cleveland, Ohio.

The 49ers elevated place kicker Matt Gay and linebacker Jalen Graham Saturday from the practice squad to face the Cleveland Browns.

The 49ers are 8-4, but they have some chinks in their armor on both sides of the ball. For instance, Purdy had three interceptions and only one touchdown pass against the Carolina Panthers last week. The 49ers defense is still formidable, but has given up over twenty points in each of their four losses.

Learn which TV channel or how to live stream the NFL Week 13 Cleveland Browns and San Francisco 49ers game, Sunday, Nov. 30.

In the second half, Purdy and Co. settled down, extending their lead with an 80-yard touchdown drive in the early stages of the third quarter. Christian McCaffrey was the one to find the end zone at that juncture, scoring from 12 yards out against his former team as he squared off against them for the first time since being traded in 2022.