One San Francisco 49ers rookie could be in line for his NFL debut when the 49ers visit the Indianapolis Colts on Monday.

The 49ers face the Colts in Indianapolis on Monday. We break down what the game means for the NFL playoff picture.

Phillip Rivers leads the Indianapolis Colts against Brock Purdy and the San Francisco 49ers tonight in this NFL Week 16 showdown.

A pair of Offensive Player of the Year candidates face off on Monday Night Football in Week 16, as Christian McCaffrey and the San Francisco 49ers hit the road

The Indianapolis Colts will look to snap a four-game losing streak when they battle the San Francisco 49ers on Monday Night Football. San Francisco is coming off a 37-24 win over the Tennessee Titans on Sunday,

Claire Kittle, who is married to 49ers tight end, George Kittle, said it "really hit home" when San Francisco briefly released veteran fullback Kyle Juszczyk before resigning him in March.

The stakes are high for several teams in the penultimate week of the NFL regular season. Here's how the odds see it going.

To clinch a playoff spot the 49ers needed the Pittsburgh Steelers to beat the Detroit Lions at Ford Field on Sunday. The seven-point underdog Steelers did San Francisco a favor by upsetting the Lions 29-24 while the 49ers sat in Indianapolis awaiting their Monday night showdown with the Indianapolis Colts.