Adenosine receptors are key neuromodulators that regulate neuronal excitability, synaptic transmission and neuroinflammation. Two principal subtypes, A1 and A2A, exert opposing effects on cAMP ...

A 1 AR Brain (cortex, hippocampus, cerebellum), spinal cord, eye, adrenal gland, atria, liver, kidney, adipose tissue, salivary glands, esophagus, colon, atrium and ...

Perhaps the most intriguing implication of recent breakthrough research lies in an unexpected connection: the most rigorous mechanistic dissection of rapid antidepressant action identifies adenosine ...

In a new study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out ...

This article is based on a poster originally authored by Philip Rawlins, Jim Reid, William Lee, Holly Madden, Soumya Dhanavade, James Craswell, Satya Bhamidimarri, Anna Hopkins, Joe Mason, Marieke ...

A recent study by researchers at the University of Florence and collaborators has demonstrated the efficacy of MRS-3997, a dual adenosine A2A/A2B receptor agonist, in reducing brain damage and ...

Chronic exposure to drugs of abuse fundamentally alters how neuromodulatory systems communicate. A central line of our research investigates exactly how psychostimulants like cocaine and ...

Tsukuba, Japan—The nucleus accumbens plays a pivotal role in motivational behavior and sleep regulation, modulated by adenosine A 2A receptors (A 2A R). Hence, selective A 2A R regulation within this ...

GPCRs are the largest receptor class, affecting almost every aspect of human physiology, with 35% of all approved drugs acting on GPCRs. They regulate sensory and neuronal signaling, as well as a ...

Adenosine deaminase 2 (ADA2) has been identified as a regulator of toll-like receptor 9 (TLR9) activation in response to nucleic acids, according to a recent study. ADA2, previously known for its role ...