San Francisco 49ers running back Christian McCaffrey takes the toss and bursts into the end zone for a 12-yard touchdown run ...

San Francisco RB Christian McCaffrey took a catch-and-run for a 25-yard gain in the team's Week 1 matchup against the Seattle Seahawks. Check out the San Francisco 49ers biggest moments and ...

McCaffrey, one of the best receiving running backs in NFL history, plays his former team on "Monday Night Football." ...

Watch the best plays from San Francisco 49ers running back Christian McCaffery's 142-yard game against the Carolina Panthers ...

EAST RUTHERFORD, N.J. (AP) — Christian McCaffrey and Brian Robinson Jr. kept getting the ball and carving through the New York Giants' defense. San Francisco 49ers coach Kyle Shanahan wondered if he ...

Christian McCaffrey plays football like he was built for it because, in many ways, he was. Competitive drive runs in his ...

SANTA CLARA, Calif. -- After another physical, grind-it-out win against the Los Angeles Rams last week, San Francisco 49ers running back Christian McCaffrey stood at a lectern with a big grin on his ...

SANTA CLARA -- Christian McCaffrey isn't having a bad season. He's playing through a calf strain, and yet he's on pace for 1,065 receiving yards this season, which would be a career high. He's still ...