If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

As people age, their immune systems deteriorate. This makes them more susceptible to infections and can mean that vaccines ...

The FDA has granted orphan drug designation (ODD) to LP-284, a next-generation acylfulvene small molecule, for the treatment ...

We performed whole-transcriptome sequencing (n = 188) and exon capture DNA sequencing (n = 208) on pretreatment tumors from the CALGB 90601 randomized trial of gemcitabine/cisplatin plus bevacizumab ...

DNA, though tightly packed in the nucleus, is constantly threatened by damage from metabolism and external stressors. One particularly severe form of DNA damage is the so-called DNA–protein crosslinks ...

Although DNA is tightly packed and safeguarded within the cell nucleus, it remains continually at risk of damage from normal ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...

A new mouse study found that unrepaired DNA-protein crosslinks activate inflammatory signaling pathways that trigger early aging disorders.

A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress. The findings of the UC ...