Get the opening NFL Week 4 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Sept. 25, 2025.

NFL Week 4 kicks off Thursday night, as the Cardinals Bills host the Seahawks. Here are the lines for every Week 4 matchup at DraftKings Sportsbook as of Sept. 28. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

NFL Week 4 betting spreads, lines, point totals for every game on the NFL Week 4 schedule, with odds for favorites and underdogs in each NFL matchup.

There are a number of intriguing matchups on the Week 7 NFL schedule, including Eagles vs. Vikings (+2.5), Packers vs. Cardinals (+6.5), Commanders vs. Cowboys (+1.5) and Buccaneers vs. Lions (-5.5) on 'Monday Night Football.

The Week 4 Thursday Night Football matchup will feature a battle between 2-1 NFC West squads, both hoping to rise up the division standings. On one side are the Seahawks, whose only loss was to undefeated San Francisco in Week 1. On the other side are the Cardinals, who fell to the Niners in Week 3.

Survivor pools continue to tighten, but Jason Logan breaks down why Mike Vrabel’s Patriots are set for a layup in Nashville.

The Buffalo Bills (4-1) will aim to get back into the win column when they visit the Atlanta Falcons (2-2) on 'Monday Night Football' in NFL Week 6. Josh Allen and the Bills were upset at home their last time out,

Thursday Night Football features a battle of 40-year-old quarterbacks as Aaron Rodgers (41-years old) and the Pittsburgh Steelers visit Cincinnati to face Joe Flacco (40-year-old) and the Bengals. The Bengals started 2-0 with Joe Burrow as the starting QB,