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Brandon Aiyuk’s tenure with 49ers likely over

NFL Insiders Reveal 49ers’ Massive Decision on Brandon Aiyuk

For anyone hoping that Brandon Aiyuk would play at least this 2025 NFL season for the San Francisco 49ers, that ship has sailed.

· 9h · on MSN

San Francisco 49ers end Brandon Aiyuk's season in roster move

· 12h · on MSN

49ers place Brandon Aiyuk on reserve list, ending his season and likely his tenure

· 11h

49ers officially end star WR's season with intriguing transaction

San Francisco 49ers wide receiver Brandon Aiyuk has been on the PUP list since the start of the season after missing the team's final 11 weeks of last year due to a torn ACL, but now his season is off...

· 12h

49ers all but guarantee Brandon Aiyuk departure with latest roster move

· 12h

Aiyuk can't play for 49ers this season after placed on reserve/left squad list

49ers get bad news on RB Christian McCaffrey

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· 25m

49ers RB Christian McCaffrey set to play in Week 15 despite back injury

The San Francisco 49ers (9-4) will face the Tennessee Titans (2-11) in Week 15 at Levi’s Stadium, with all eyes on star running back Christian McCaffrey.

49ers Webzone · 3h

Another NFL insider expects 49ers RB Christian McCaffrey to play vs. Titans

· 10h

Titans at 49ers: Predictions, picks and odds for NFL Week 15 game

· 22h

Titans vs 49ers picks as Cam Ward, Tennessee can shake up San Francisco's playoff chances

The Tennessee Titans can add another road win with a trip to the San Francisco 49ers on Dec. 14 at Levi's Stadium in Santa Clara.

Niners Wire · 4h

49ers Week 15 rooting guide: Who San Francisco should pull for?

· 12h

Tennessee Titans at San Francisco 49ers odds, picks and predictions

· 12h

49ers elevate a pair of defenders ahead of their Week 15 matchup against the Titans

Linebacker Jalen Graham was activated from the practice squad, as was defensive lineman Sebastian Valdez.

· 12h

Tennessee Titans vs. San Francisco 49ers: 6 keys to victory in Week 15

· 16h

A handful of former 49ers will return to Levi’s Stadium in a Titans uniform on Sunday

16h

Latest Brandon Aiyuk Rumors on 49ers Future, Potential Timeline for Resolution

The Athletic's Dianna Russini is expecting an answer in the near future as to whether Brandon Aiyuk will play another game for the San Francisco 49ers.

9hon MSN

NFL Injury Report: 49ers’ game plan in limbo after Christian McCaffrey unexpectedly lands on injury report before Titans game

San Francisco 49ers star Christian McCaffrey's availability for Sunday's game against the Titans is uncertain due to a back issue, despite earlier opt

12hon MSN

49ers Receive Concerning Christian McCaffrey News Before Titans Game

The San Francisco 49ers have received some very concerning news regarding superstar running back Christian McCaffrey.

Niners Wire on MSN

49ers DE posts hilarious vote for the NFL Top 100

McCaffrey has been the engine of the San Francisco offense, ranking fifth in the NFL in receptions and near the top of the league in total touches. Through 13 games, he has 237 carries and 85 catches, producing 1,655 yards from scrimmage and 13 total touchdowns.