The 49ers are seeking a third straight victory on the road despite a 5-5 record. Star running back Christian McCaffrey has returned to the 49ers offense after spending most of the season on injured reserve and has 213 total yards over his first two games. San Francisco lost at home last week, though, 20-17 to Seattle.

Coming off a stunning 20-19 victory over the Chicago Bears on a last-second blocked field goal, the Green Bay Packers are taking on the San Francisco 49ers on Sunday at Lambeau Field. The Packers' performance against the Bears left a lot of questions.