Compare and contrast the classical pathway of complement activa... | Filo
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✨Complement Coagulation Pathway✨ 🔸Interconnection between two major plasma cascade systems in the body: the Complement system (innate immunity) and the Coagulation system (blood clotting). 💐Complement Pathway💐 3 activation routes, all converging at the formation of C3 convertase → C5 convertase → Membrane Attack Complex (MAC, C5b–9): 🔸1.Classical pathway → triggered by Ag–Ab complexes (IgG, IgM) 🔸2.Lectin pathway → triggered by Mannose-binding lectin (MBL) 🔸3.Alternative pathway → triggere
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Code HAVIC @medschoolbro = Mystery Discount Complement System: 30-sec Review 🛣 Three pathways lead to complement activation: • Classical pathway activated by IgG or IgM • Alternative pathway activated by microbial surfaces • Lectin pathway activated by mannose on microbes 🌀 C3 convertase produces C3a and C3b. 🔥 C5 convertase produces C5a and C5b. 💥 MAC (C5b–C9) forms pores that destroy microbes, especially Neisseria. 🔑 Key functions: • C3a and C5a trigger mast cell degranulation • C5a direc
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